Difference between osteomyelitis and septic arthritis. Typically, septic arthritis affects one large joint in the body, such as the knee or hip. Septic arthritis develops when bacteria or other tiny diseasecausing organisms microorganisms spread through the blood to a joint. In all cases of suspected native joint sepsis, the joint should be aspirated. Neisseria gonorrhoeae, the bacteria that causes gonorrhea, is a common pathogen affecting sexually active young adults. These infections can affect any joint or bone in the body and are most commonly caused by staphylococcus aureus. Septic arthritis, also known as infectious arthritis, may represent a direct invasion of joint space by various microorganisms, most commonly caused by bacteria. Acute infectious arthritis is a joint infection that evolves over hours or days. It is the purulent invasion of a joint by an infectious agent which produces arthritis.
Pdf the incidence of septic arthritis appears to be increasing, which may be accounted for by the increasing use of immunosuppressive. Background, etiology and pathophysiology, prognosis. Most kinds of arthritis cause pain and swelling in your joints. Septic arthritis is inflammation of a joint due to a bacterial or fungal infection. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Interactions between conserved pathogenic signals and host recognition systems initiate a systemic reaction to local infection. The differential diagnoses for osteoarthritis will depend on which area of the body is affected. Other symptoms may include fever, weakness and headache. Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is staphylococcus aureus. The main causative organisms that lead to septic arthritis are s. Posttraumatic septic arthritis has a different clinical and microbiological pattern to primary native joint arthritis. Joint pain that is sudden in onset is more suggestive of intrinsic joint pathology, such as septic arthritis.
Septic arthritis typically presents as a hot, swollen, tender joint or joints with a reduced range of movement. Fifty percent of adults with septic arthritis have significant decreased rom or chronic pain after the infection. Symptoms typically include redness, heat and pain in a single joint associated with a decreased ability to move the joint. Diagnosis is based on the opinion of the clinician experienced in the management of musculoskeletal disease. Septic arthritis refers to the infection of a joint. Pathophysiology process of malignant intravascular inflammation malignant uncontrolled, unregulated, and selfsustaining intravascular bloodborne spread of what is usually a celltocell interaction in the interstitial space inflammation all characteristics of septic response are exaggerations of the normal. Pro and antiinflammatory intermediates and associated coagulatory abnormalities lead to altered macrovascular, microvascular, and mitochondrial function. Symptoms include pain and tenderness over a joint, pain on moving the joint, and feeling unwell. In children younger than 18 months, septic arthritis is often secondary to osteomyelitis, which has eroded through the boney.
Key difference osteomyelitis vs septic arthritis both osteomyelitis and septic arthritis are two infections affecting the skeletal system. Future management of septic arthritis open access journals. The condition is an inflammation of a joint thats caused by infection. Arthroscopic debridement of the knee for septic arthritis. Bacteria enter joint and deposit in synovial lining. Septic arthritis in the adult caused by streptococcus pneumoniae. Introduction septic arthritis is inflammation of a synovial membrane with purulent effusion into the joint capsule, due to infection. Acute infectious arthritis msd manual professional edition. The epidemiology, pathogenesis, microbiology, treatment, and outcome of bacterial arthritis in infants. Septic arthritis is microbial invasion of the joint space with a subsequent inflammatory response, and is most commonly caused by a bacterial infection. The infection resides in synovial or periarticular tissues and is usually bacterialin younger adults, frequently neisseria gonorrhoeae. The role of trauma in the pathogenesis remains unclear.
This includes antibiotic medicines and drainage of infected fluid from the joint to prevent permanent joint damage. It is defined as an acute or chronic joint inflammation that often coexists with pain and structural damage. Septic arthritis is also known as infectious arthritis, bacterial, or fungal arthritis. Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by an infectious agent resulting in joint inflammation. Reactive arthritis is a sterile inflammatory process that may result from an extraarticular infectious process.
Joints are places where two bones meet, such as your elbow or knee. Pdf traumarelated septic arthritis is a rare and serious infection. Although prompt responses are reported in nonsicklers, escherichia coli and salmonella enteritidis persisted in joints of sicklemic patients for 53 and 42 days in spite of extraordinary doses of parenteral antibiotics. A septic joint will be painful, hot, swollen, and restricted. Although a multitude of organisms may cause arthritis, staphylococcus aureus is the most common pathogen. Introduction pathogenesis clinical features investigations treatment 3. Summary acute septic arthritis may develop as a result of hematogenous seeding, direct introduction, or extension from a contiguous focus of infection. However, viruses, mycobacteria, and fungi have been implicated. Septic arthritis of the knee pathophysiology, diagnostics, and therapy. Pathophysiology septic arthritis may result from hematogenous seeding of the joint, or to direct spread from a contiguous focus of osteomyelitis.
An infection of the bones is identified as osteomyelitis whereas an infection of the joints is called septic arthritis. Neisseria gonorrhoeae and staphylococcus aureus are used in discussing the hostpathogen interaction in the pathogenesis of acute septic arthritis. It requires a high index of suspicion and can affect both native and prosthetic joints. The term septic arthritis usually refers to bacterial arthritis or fungal arthritis, but bacterial joint infections are most common. The pathogenesis of staphylococcal septic arthritis is highly simplified and depicted schematically in figure 1. Approach to septic arthritis american family physician. The pathophysiology of sepsis is the result of a dysregulated host response to infection.
Synovial fluid gases were measured in one patient before, during, and after septic. Joint specific differential diagnoses for osteoarthritis. Mortality ranges from 1925% permanent joint disability occurs in 25 50% of the cases. Arthritis is derived from the greek term disease of the joints. The unique circulation about the hip in infancy makes septic arthritis a common complication of proximal femoral osteomyelitis. The pathogenesis of acute septic arthritis is multifactorial and depends on the interaction of the host immune response and the adherence factors, toxins, and immunoavoidance strategies of the invading pathogen.380 1203 16 672 1502 1466 948 319 890 1533 641 27 1540 576 884 350 605 146 349 405 1041 833 18 1449 581 964 105 358 1270 639 1484 884 1226 1147 1217